Ca2+ Signaling: regulatory mechanisms to impact on health and diseases

Session #2- ER Calcium homeostasis and its role in cellular physiology (9:00-10:40am)
Chair: Avinash Bajaj, Regional Centre for Biotechnology, India

09:00 am - 09:25 am

In Vivo imaging of intracellular Ca2+ dynamics in salivary glands
David Yule, University of Rochester Medical Center, USA

09:25 am - 09:50 am

Modulation of neuronal function by intracellular calcium signaling
Gaiti Hasan, National Centre for Biological Sciences, India

09:50 am - 10:15 am

Advances in understanding and exploiting Ca2^+- signaling modulation by anti-apoptotic Bcl-2
Geert Bultynck, KU Leuven, Belgium

10:15 am - 10:40 am

Leucine-rich repeat-containing 8A (LRRC8A) is a negative modulator of store-operated Ca 2+ entry
Amal Kanti Bera, Indian Institute of Technology Madras, India

10:40 am - 11:15 am

Tea + Networking

Session #3- Mitochondrial Calcium signaling (11:15-1:00 pm)
Chair: Deepak Nair, Regional Centre for Biotechnology, India
Klaus Groschner, Medical University of Graz, Austria

11:15 am - 11:40 am

A chloroplast-localized mitochondrial calcium uniporter transduces osmotic stress in Arabidopsis model plants
Ildiko Szabo, University of Padova, Italy

11:40 am - 12:05 pm

Physiological role and regulation of the mitochondrial Na+/Ca++ exchanger NCLX
Israel Sekler, Ben Gurion University, Israel

12:05 pm - 12:30 pm

ORAI calcium channels in physiology and disease
Mohamed Trebak, Penn State Medical Center, USA

12:30 pm - 12:45 pm

Plant calcium channel CNGC19 is crucial to defend against insect herbivore Spodoptera litura
Jyothilakshmi Vadassery, NIPGR, India

12:45 pm - 01:00 pm

HIF-1α induces calcium influx in the glomerular podocytes and contributes to proteinuria
Anil Kumar Pasupulati, University of Hyderabad, India

01:00 pm - 02:00 pm

Lunch + Networking

Session #4- Calcium microdomains and cell functions (2:00-3:40pm)
Chair: Sivaram Mylavarapu, Regional Centre for Biotechnology, India

02:00 pm - 02:25 pm

NAADP, Two-pore Channels and Acidic Ca2+ Stores
Sandip Patel, University College London, UK

02:25 pm - 02:50 pm

Molecular mechanisms of calcium signaling during phagocytosis
Nicolas Demaurex, University of Geneva, Switzerland

02:50 pm - 03:15 pm

Dissection of a novel signaling cascade in malaria parasite
Pushkar Sharma, National Institute of Immunology, India

03:15 pm - 03:40 pm

Suppression of Ca2+ Signals by EGR4 controls Th1 differentiation and anti-cancer immunity in vivo
Jonathan Soboloff, Lewis Katz School of Medicine, Temple University, USA

03:40 pm - 04:10 pm

Tea + Networking

Session #5: Targeting calcium signaling for managing pathophysiology (4:10-5:05pm)
Chair: Manjula Kalia, Regional Centre for Biotechnology, India

04:10 pm - 04:35 pm

Plasmodium falciparum Perforin like proteins triggred intracellular calcium and eryptosis in bystander erythrocytes contribute to malaria-induced anemia and pathogenesis
Shailja Singh, Jawaharlal Nehru University, New Delhi, India

04:35 pm - 04:50 pm

Urotensin II receptor antagonization, a potential therapeutic approach for Chronic Heart Failure
Ruchi Tandon, Translational Health Science and Technology Institute, India

04:50 pm - 05:05 pm

iCa2+ flux, ROS and IL-10 determines cytotoxic and suppressor T cell functions in chronic human viral infections
Subhasmita Mohanty, Institute of Life Sciences, India

05:05 pm - 05:45 pm

Intro to the Speaker: Mohamed Trebak, Penn State, USA
Keynote lecture: Pharmacologic tools probe mitochondrial behavior in health and disease
Madesh Muniswamy, UT Health San Antanio, USA

05:45 pm - 06:00 pm

Poster Awards, Closing Remarks and Vote of Thanks
Prof. Sudhanshu Vrati, Executive Director, RCB and Dr. Deepika Bhaskar, Registrar, RCB

06:00 pm

Friday

31st January, 2020

Saturday

1st Feburary, 2020

Registration

Lunch + Posters setup

Welcome by: Prof. Sudhanshu Vrati, Executive Director, RCB Dr. Deepika Bhaskar, Registrar, RCB About the Symposium (Rajender Motiani, RCB)

Intro to the Speaker: Indu Ambudkar, NIH, USA Plenary Lecture: The pancreas, calcium and the gut microbiome Shmuel Muallem, NIH, USA

Poster session + High Tea

Session#1: Store Operated Calcium Entry in health and disease (5:45-7:30pm) Chair: Rajesh S Gokhale, National Institute of Immunology, India

Ion channels regulating immune function: CRAC channels and beyond Stefan Feske, NYU School of Medicine, USA

Regulation of synaptic plasticity and cognitive functions by store-operated Orai1 channels Murali Prakriya, Feinberg School of Medicine, Northwestern University, USA

SOCE defects underlie radiation-induced salivary gland hypofunction Indu Ambudkar, NIH, USA

Short talk 1: Ca2+/Calmodulin-dependent regulation of the MiT-TFE transcription factor Rainer Schindl, University of Graz, Austria

Short talk 2: Calmodulin coordinates the slow Ca2+-dependent inactivation of the Ca2+ release-activated Ca2+ channel through STIM1 Rajesh Bhardwaj, University of Bern, Switzerland

Dinner + Networking

Session #2- ER Calcium homeostasis and its role in cellular physiology (9:00-10:40am) Chair: Avinash Bajaj, Regional Centre for Biotechnology, India

In Vivo imaging of intracellular Ca2+ dynamics in salivary glands David Yule, University of Rochester Medical Center, USA

Modulation of neuronal function by intracellular calcium signaling Gaiti Hasan, National Centre for Biological Sciences, India

Advances in understanding and exploiting Ca2+- signaling modulation by anti-apoptotic Bcl-2 Geert Bultynck, KU Leuven, Belgium

Leucine-rich repeat-containing 8A (LRRC8A) is a negative modulator of store-operated Ca 2+ entry Amal Kanti Bera, Indian Institute of Technology Madras, India

Tea + Networking

Session #3- Mitochondrial Calcium signaling (11:15-1:00 pm) Chair: Deepak Nair, Regional Centre for Biotechnology, IndiaKlaus Groschner, Medical University of Graz, Austria

A chloroplast-localized mitochondrial calcium uniporter transduces osmotic stress in Arabidopsis model plants Ildiko Szabo, University of Padova, Italy

Physiological role and regulation of the mitochondrial Na+/Ca++ exchanger NCLX Israel Sekler, Ben Gurion University, Israel

ORAI calcium channels in physiology and disease Mohamed Trebak, Penn State Medical Center, USA

Plant calcium channel CNGC19 is crucial to defend against insect herbivore Spodoptera litura Jyothilakshmi Vadassery, NIPGR, India

HIF-1α induces calcium influx in the glomerular podocytes and contributes to proteinuria Anil Kumar Pasupulati, University of Hyderabad, India

Lunch + Networking

Session #4- Calcium microdomains and cell functions (2:00-3:40pm) Chair: Sivaram Mylavarapu, Regional Centre for Biotechnology, India

NAADP, Two-pore Channels and Acidic Ca2+ Stores Sandip Patel, University College London, UK

Molecular mechanisms of calcium signaling during phagocytosis Nicolas Demaurex, University of Geneva, Switzerland

Dissection of a novel signaling cascade in malaria parasite Pushkar Sharma, National Institute of Immunology, India

Suppression of Ca2+ Signals by EGR4 controls Th1 differentiation and anti-cancer immunity in vivo Jonathan Soboloff, Lewis Katz School of Medicine, Temple University, USA

Tea + Networking

Session #5: Targeting calcium signaling for managing pathophysiology (4:10-5:05pm) Chair: Manjula Kalia, Regional Centre for Biotechnology, India

Plasmodium falciparum Perforin like proteins triggred intracellular calcium and eryptosis in bystander erythrocytes contribute to malaria-induced anemia and pathogenesis Shailja Singh, Jawaharlal Nehru University, New Delhi, India

Urotensin II receptor antagonization, a potential therapeutic approach for Chronic Heart Failure Ruchi Tandon, Translational Health Science and Technology Institute, India

iCa2+ flux, ROS and IL-10 determines cytotoxic and suppressor T cell functions in chronic human viral infections Subhasmita Mohanty, Institute of Life Sciences, India

Intro to the Speaker: Mohamed Trebak, Penn State, USA Keynote lecture: Pharmacologic tools probe mitochondrial behavior in health and disease Madesh Muniswamy, UT Health San Antanio, USA

Poster Awards, Closing Remarks and Vote of Thanks Prof. Sudhanshu Vrati, Executive Director, RCB and Dr. Deepika Bhaskar, Registrar, RCB

High Tea + Departure

Welcome by:
Prof. Sudhanshu Vrati, Executive Director, RCB
Dr. Deepika Bhaskar, Registrar, RCB
About the Symposium (Rajender Motiani, RCB)

Intro to the Speaker: Indu Ambudkar, NIH, USA
Plenary Lecture: The pancreas, calcium and the gut microbiome Shmuel Muallem, NIH, USA

Session#1: Store Operated Calcium Entry in health and disease (5:45-7:30pm)
Chair: Rajesh S Gokhale, National Institute of Immunology, India

Ion channels regulating immune function: CRAC channels and beyond
Stefan Feske, NYU School of Medicine, USA

Regulation of synaptic plasticity and cognitive functions by store-operated Orai1 channels
Murali Prakriya, Feinberg School of Medicine, Northwestern University, USA

SOCE defects underlie radiation-induced salivary gland hypofunction
Indu Ambudkar, NIH, USA

Short talk 1: Ca2+/Calmodulin-dependent regulation of the MiT-TFE transcription factor
Rainer Schindl, University of Graz, Austria

Short talk 2: Calmodulin coordinates the slow Ca2+-dependent inactivation of the Ca2+ release-activated Ca2+ channel through STIM1
Rajesh Bhardwaj, University of Bern, Switzerland

Session #2- ER Calcium homeostasis and its role in cellular physiology (9:00-10:40am)
Chair: Avinash Bajaj, Regional Centre for Biotechnology, India

In Vivo imaging of intracellular Ca2+ dynamics in salivary glands
David Yule, University of Rochester Medical Center, USA

Modulation of neuronal function by intracellular calcium signaling
Gaiti Hasan, National Centre for Biological Sciences, India

Advances in understanding and exploiting Ca2^+- signaling modulation by anti-apoptotic Bcl-2
Geert Bultynck, KU Leuven, Belgium

Leucine-rich repeat-containing 8A (LRRC8A) is a negative modulator of store-operated Ca 2+ entry
Amal Kanti Bera, Indian Institute of Technology Madras, India

Session #3- Mitochondrial Calcium signaling (11:15-1:00 pm)
Chair: Deepak Nair, Regional Centre for Biotechnology, India
Klaus Groschner, Medical University of Graz, Austria

A chloroplast-localized mitochondrial calcium uniporter transduces osmotic stress in Arabidopsis model plants
Ildiko Szabo, University of Padova, Italy

Physiological role and regulation of the mitochondrial Na+/Ca++ exchanger NCLX
Israel Sekler, Ben Gurion University, Israel

ORAI calcium channels in physiology and disease
Mohamed Trebak, Penn State Medical Center, USA

Plant calcium channel CNGC19 is crucial to defend against insect herbivore Spodoptera litura
Jyothilakshmi Vadassery, NIPGR, India

HIF-1α induces calcium influx in the glomerular podocytes and contributes to proteinuria
Anil Kumar Pasupulati, University of Hyderabad, India

Session #4- Calcium microdomains and cell functions (2:00-3:40pm)
Chair: Sivaram Mylavarapu, Regional Centre for Biotechnology, India

NAADP, Two-pore Channels and Acidic Ca2+ Stores
Sandip Patel, University College London, UK

Molecular mechanisms of calcium signaling during phagocytosis
Nicolas Demaurex, University of Geneva, Switzerland

Dissection of a novel signaling cascade in malaria parasite
Pushkar Sharma, National Institute of Immunology, India

Suppression of Ca2+ Signals by EGR4 controls Th1 differentiation and anti-cancer immunity in vivo
Jonathan Soboloff, Lewis Katz School of Medicine, Temple University, USA

Session #5: Targeting calcium signaling for managing pathophysiology (4:10-5:05pm)
Chair: Manjula Kalia, Regional Centre for Biotechnology, India

Plasmodium falciparum Perforin like proteins triggred intracellular calcium and eryptosis in bystander erythrocytes contribute to malaria-induced anemia and pathogenesis
Shailja Singh, Jawaharlal Nehru University, New Delhi, India

Urotensin II receptor antagonization, a potential therapeutic approach for Chronic Heart Failure
Ruchi Tandon, Translational Health Science and Technology Institute, India

iCa2+ flux, ROS and IL-10 determines cytotoxic and suppressor T cell functions in chronic human viral infections
Subhasmita Mohanty, Institute of Life Sciences, India

Intro to the Speaker: Mohamed Trebak, Penn State, USA
Keynote lecture: Pharmacologic tools probe mitochondrial behavior in health and disease
Madesh Muniswamy, UT Health San Antanio, USA

Poster Awards, Closing Remarks and Vote of Thanks
Prof. Sudhanshu Vrati, Executive Director, RCB and Dr. Deepika Bhaskar, Registrar, RCB