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Dr. Karthigeyan Dhanasekaran

Assistant Professor
Centrosome and Cilia biology lab
E-mail: karthigeyan at rcb dot res dot in

  • PhD (Molecular Biology and Genetics) 2013, JNCASR, Bangalore.
  • MVSc (Molecular Biology and Biotechnology), G. B. Pant University of Agriculture and Technology, Pantnagar, 2007.
  • Post-doctoral Research at the Yale School of Medicine, USA, 2015.
  • Assistant Professor at the RCB, since 2020.

Centrosomes were discovered towards the end of nineteenth century as a membrane less self-replicating, microtubule based organelle, and presently well established as a microtubule organising centre in most of the cells. Yet its role is not fully understood beyond spindle assembly and cell division.

With the advent of proteomic tools, we have started gaining better insights off late in terms of the composition and functioning of centrosomes across various tissue types. Also we have now started to explore the evolutionary aspects of centrosome at the organismal level. Similarly, the related structures like flagella and cilia have also gained attention in the recent past as we discover more cilia related disorders or ciliopathies in general.

Often centriole associated structures like centrosome, centriolar satellite and ciliary basal bodies are regulated by means of common pathways at the same point of time in a well-coordinated fashion to establish the necessary dynamics as per the requirement of every cell division and differentiation. We are now realising much more robust functioning of these structures in regulating events beyond cell division like subcellular trafficking, intracellular signalling, polarity establishment, development and differentiation. On the contrary these structures are totally dispensable for certain cellular milieu in some instances like skeletal myotube formation for example.

At this juncture we believe that a more robust investigation is warranted to understand these subcellular structures using basic biochemical and molecular cell biology approaches combining the tools of modern proteomics and super-resolution imaging techniques. Our lab will be broadly interested in studying,

  • The role of centrosomes in regulation infectious pathobiology.
  • Nature of signalling components operating across centrosome and cilia.
  • Contribution of centriolar satellites in the dynamics of centrosome and cilia related events.
  • DNA damage response related functioning and to have a better understanding of DNA repair factor’s roles in centrosome and basal body maintenance.
  • Targeting centrosomes as a node for drug intervention to combat the associated pathology.
    • Awarded Senior Research Fellowship (SRF), by Council of Scientific and Industrial Research, Government of India in years 2009 and 2013.
    • Awarded Junior Research Fellowship (JRF) from Council of Scientific and Industrial Research (CSIR), Government of India (2007-2005).
    • Topper in Junior Research Fellowship (JRF) from Department of Biotechnology (DBT), Government of India, (2007 not activated).
    • Dr. Wilson Memorial medal, Madras Veterinary College, TANUVAS, 2005.
    • All India 5 th rank in ICAR Junior Research Fellowship in Biochemistry and biotechnology stream (2005 not activated).
    • 3 rd rank in Veterinary Biotechnology Junior Research Fellowship for Master degree in Biotechnology by Department of Biotechnology (JNU-DBT), from 2005 to 2007.
    • JB poster prize for best poster presented in the 5th Asian Chromatin Meeting, Jan, 2015 held at JNCASR, Bangalore, India.
    • JB Prize for 2013 instituted by The Japanese Biochemical Society for the publication Vasudevarao M D, and Karthigeyan D, et al; J.Biochem 2012; 152(5):453, chosen as the winning paper among all the papers published in the Journal of Biochemistry in 2012.
    • ACS chemical biology-Best poster Award during the International Symposium on Challenges in Chemical Biology, held at IICB, Kolkata, from 27 th -19 th Jan, 2013.
    • DST travel grant for 11 th EMBL Conference held at Heidelberg, Germany, 2013.
    • JSPS travel grant for attending Eleventh Asian Conference on transcription held at Okinawa, Japan, 2010.
    1. Karthigeyan Dhanasekeran, Nidhi Vishnoi, Madeleine Chalfant, Ivan Surovstev, Mustafa K. Khokha and C. Patrick Lusk. (2020) Differential turnover of Nup188 controls its levels at centrosomes and role in centriole duplication. J Cell Biol 219 (3), e201906031
    2. D Karthigeyan, A Bose, R Boopathi, VJ Rao, H Shima, N Bharathy, K Igarashi, R Taneja, A K Trivedi, Tapas K Kundu (2020) Aurora kinase A-mediated phosphorylation of mPOU at a specific site drives skeletal muscle differentiation. The Journal of Biochemistry 167 (2), 195-201
    3. K Dhanasekaran, A Bose, VJ Rao, R Boopathi, SR Shankar, VK Rao, A Swaminathan, M Vasudevan, R Taneja and Tapas K Kundu (2019) Unraveling the role of Aurora A beyond centrosomes and spindle assembly: implications in muscle differentiation. The FASEB Journal 33 (1), 219-230
    4. K Dhanasekaran, S Kumari, R Boopathi, H Shima, A Swaminathan, M Bachu, U Ranga, K Igarashi and Tapas K Kundu (2016) Multifunctional human transcriptional coactivator protein PC4 is a substrate of Aurora kinases and activates the Aurora enzymes. The FEBS Journal 283 (6), 968-985
    5. D Karthigeyan, S Surabhi, P Mizar, S Soumik, A Banerjee, SH Sinha, D Dasgupta, C Narayana and Tapas K Kundu (2016) A Dual Non‐ATP Analogue Inhibitor of Aurora Kinases A and B, Derived from Resorcinol with a Mixed Mode of Inhibition. Chemical Biology & Drug Design 87 (6), 958-967
    6. D Karthigeyan, S Siddhanta, AH Kishore, SSRR Perumal, H Ågren, S Sudevan, A V Bhat, K Balasubramanyam, K S Rangappa, Tapas K Kundu and C Narayana (2014) SERS and MD simulation studies of a kinase inhibitor demonstrate the emergence of a potential drug discovery tool. Proceedings of the National Academy of Sciences 111 (29), 10416-10421
    7. J Shandilya, P Senapati, K Dhanasekaran, SS Bangalore, M Kumar, A H Kishore, A Bhat, G S Kodaganur and Tapas K Kundu (2014) Phosphorylation of multifunctional nucleolar protein nucleophosmin (NPM1) by aurora kinase B is critical for mitotic progression. FEBS letters 588 (14), 2198-2205
    8. S Siddhanta, D Karthigeyan, PP Kundu, TK Kundu, C Narayana (2013) Surface enhanced Raman spectroscopy of Aurora kinases: direct, ultrasensitive detection of autophosphorylation. RSC advances 3 (13), 4221-4230
    9. K Dhanasekaran, S Kumari, C Kanduri (2013) Noncoding RNAs in chromatin organization and transcription regulation: an epigenetic view. Epigenetics: Development and Disease, Subcell Biochem 61, 343-372
    10. K Dhanasekaran, M Arif, TK Kundu (2013) Cancer: An epigenetic landscape. Epigenetics: Development and disease, Subcell Biochem 61, 399-417
    11. M Arif, D Karthigeyan, S Siddhanta, GVP Kumar, C Narayana, TK Kundu (2013) Analysis of Protein Acetyltransferase Structure–Function Relation by Surface-Enhanced Raman Scattering (SERS): A Tool to Screen and Characterize Small Molecule Modulators. Methods Mol Biol 981, 239-261
    12. M Dalvoy Vasudevarao, K Dhanasekaran, RB Selvi, TK Kundu (2012) Inhibition of acetyltransferase alters different histone modifications: probed by small molecule inhibitor plumbagin. The journal of biochemistry 152 (5), 453-462
    13. D Karthigeyan, SBB Prasad, J Shandilya, S Agrawal, TK Kundu (2011) Biology of Aurora A kinase: Implications in cancer manifestation and therapy. Medicinal research reviews 31 (5), 757-793

    Dr. Karthigeyan Dhanasekaran M.V.Sc, Ph.D.
    Centrosome and Cilia biology lab
    Regional Centre for Biotechnology
    NCR Biotech Science Cluster
    3rd Milestone, Faridabad-Gurgaon Expressway
    P.O. Box No. 3, Faridabad - 121 001
    Haryana (NCR Delhi), India
    e-mail: karthigeyan at rcb dot res dot in
    Phone: 91 0129-2848739

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