Assistant Professor
Centrosome and Cilia biology lab
E-mail: karthigeyan at rcb dot res dot in
Centrosomes were discovered towards the end of nineteenth century as a membrane less self-replicating, microtubule based organelle, and presently well established as a microtubule organising centre in most of the cells. Yet its role is not fully understood beyond spindle assembly and cell division.
With the advent of proteomic tools, we have started gaining better insights off late in terms of the composition and functioning of centrosomes across various tissue types. Also we have now started to explore the evolutionary aspects of centrosome at the organismal level. Similarly, the related structures like flagella and cilia have also gained attention in the recent past as we discover more cilia related disorders or ciliopathies in general.
Often centriole associated structures like centrosome, centriolar satellite and ciliary basal bodies are regulated by means of common pathways at the same point of time in a well-coordinated fashion to establish the necessary dynamics as per the requirement of every cell division and differentiation. We are now realising much more robust functioning of these structures in regulating events beyond cell division like subcellular trafficking, intracellular signalling, polarity establishment, development and differentiation. On the contrary these structures are totally dispensable for certain cellular milieu in some instances like skeletal myotube formation for example.
At this juncture we believe that a more robust investigation is warranted to understand these subcellular structures using basic biochemical and molecular cell biology approaches combining the tools of modern proteomics and super-resolution imaging techniques. Our lab will be broadly interested in studying,
Dr. Karthigeyan Dhanasekaran M.V.Sc, Ph.D.
Centrosome and Cilia biology lab
Regional Centre for Biotechnology
NCR Biotech Science Cluster
3rd Milestone, Faridabad-Gurgaon Expressway
P.O. Box No. 3, Faridabad - 121 001
Haryana (NCR Delhi), India
e-mail: karthigeyan at rcb dot res dot in
Phone: 91 0129-2848739