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Dr. Avinash Bajaj

Associate Professor
E-mail: bajaj at rcb dot res dot in

  • PhD 2008, Indian Institute of Science
  • Postdoc at University of Massachusetts,USA

  • Dr. Siddhi Gupta
    Young Investigator
    siddhi.biotech@gmail.com
  • Dr. Madhurima Mitra, PhD
    madhurima@rcb.res.in
  • Dr. Amit Rajora, PhD
    amit.rajora@rcb.res.in
  • Sandeep Kumar
    Senior Research Fellow
    sandeep.kumar@rcb.res.in
  • Mr. Nihal Medatwal
    Senior Research Fellow
    nihal.medatwal@rcb.res.in
  • Mr. Sanjay Pal
    Senior Research Fellow
    sanjay.pal@rcb.res.in
  • Mr. Animesh Kar
    Junior Research Fellow
    animesh@rcb.res.in
  • Priyanka Verma
    Junior Research Fellow
    Priyanka.verma@rcb.res.in
  • Poonam Yadav
    Junior Research Fellow
    poonam.yadav@rcb.res.in
  • Mr. Deepak Mishra
    Junior Research Fellow
    deepak.mishra@rcb.res.in
  • Parul Tomar
    Junior Research Fellow
    parultomar25@rcb.res.in
  • Ragini Gupta
    Junior Research Fellow
    ragini.gupta@rcb.res.in
  • Mohd. Nafees Ansari
    Junior Research Fellow
    nafees.ansari@rcb.res.in
  • Trishna Pani
    Junior Research Fellow
    trishna.pani@rcb.res.in
  • Varun Kumar
    Project Assistant
    1. Pal S, Medatwal N, Kumar S, Kar A, Komalla V, Yavvari P.S., Mishra D, Rizvi Z.R., Nandan S, Malakar D, Pillai M, Awasthi A, Das P, Sharma R. D., Srivastava A, Sengupta S, Dasgupta U, and Bajaj A (2019) A Localized Chimeric Hydrogel Therapy Combats Tumor Progression through Alteration of Sphingolipid Metabolism ACS Central Sci | doi.org/10.1021/acscentsci.9b00551
    2. Gupta S, Thakur J, Pal S, Gupta R, Mishra D, Kumar S, Yadav K, Saini A, Yavvari P, Vedantham M, Singh A, Srivastava A, Prasad R and Bajaj A (2019) Cholic Acid-Peptide Conjugates (CAPs) as Potent Antimicrobials against Interkingdom Polymicrobial Biofilms. Antimicrobial Agents Chemotherapy | DOI: 10.1128/AAC.00520-19
    3. Kumar S, Thakur J, Yadav K, Mitra M, Pal S, Ray A, Gupta S, Medatwal N, Gupta R, Mishra D, Rani P, Padhi S, Sharma P, Kapil Ar, Srivastava A, Priyakumar, U Deva, Dassgupta U, Thukral L, Bajaj A. (2019) Cholic Acid-Derived Amphiphile can Combat Gram-Positive Bacteria-mediated Infections via Disintegration of Lipid Clusters. ACS Biomaterials Sci & Eng. | Doi.org/10.1021/acsbiomaterials.9b00706
    4. Kidwai S, Bouzeyne R, Chakraborti S, Khare N, Das S, Gosain T, Behura A, Meena C, Dhiman R, Essafi M, Bajaj A, Saini D, Srinivasan N, Mahajan D and Singh R. (2019) NU-6027 inhibits growth of Mycobacterium tuberculosis by targeting Protein Kinase D and Protein Kinase G. Antimicrobial Agents Chem | DOI: 10.1128/AAC.00996-19
    5. Sreekanth V and Bajaj A (2019) Recent Advances in Engineering of Lipid-Drug Conjugates for Cancer Therapy.ACS Biomaterials Sci. & Eng | Doi.org/10.1021/acsbiomaterials.9b00689
    6. Sharma Y, Ahmad A, Yavvari PS, Kumar S, Bajaj A, Khan F (2019) Targeted SHP-1 silencing modulates macrophage phenotype leading to metabolic improvement in dietary obese mice. Molecular Therapy Nucleic Acids | (In Press)
    7. Kandanur SGS, Kundu S, Cadena C., Juan HS, Bajaj A, Guzman JD, Nanduri S, Golakoti NR, (2019) Design, synthesis, and biological evaluation of new 12‐substituted‐14‐deoxy‐andrographolide derivatives as apoptosis inducers. Chemistry Lett | doi.org/10.1007/s11696-019-00718-9
    8. Yavvari PS, Verma P, Mustfa S, Pal S, Kumar S, Awasthi AK, Ahuja V, Srikanth CV, Srivastava A, and Bajaj A, (2019) A Nanogel Based Oral Gene Delivery System Targeting SUMOylation Machinery to Combat Gut Inflammation. Nanoscale (Just Accepted) | DOI: 10.1039/C8NR09599J
    9. Srivastava A, Yavvari PS, Awasthi AK, Sharma A, Bajaj A. (2019) Emerging Biomedical Applications of Polyaspartic Acid-Derived Biodegradable Polyelectrolytes and Polyelectrolyte Complexes. J. Mater. Chem. | DOI: 10.1039/C8TB02962H
    10. Mitra M, Asad M, Kumar S, Yadav K, Chaudhary S, Bhavesh N.S., Khalid S, Thukral L and Bajaj A (2019) Distinct Intramolecular Hydrogen Bonding Dictates Antimicrobial Action of Membrane-Targeting Amphiphiles. J. Phys. Chem. Lett | DOI: 10.1021/acs.jpclett.8b03508 (Just Accepted Manuscript)
    11. Yadav K, Kumar S, Mishra S, Asad M, Mitra M, Yavvari PS, Gupta S, Vedantham M, Ranga P, Komalla V, Pal S, Sharma P, Kapil A, Singh A, Singh N, Srivastava A, Thukral L and Bajaj A (2019)Deciphering the Role of Intramolecular Networking in Cholic Acid-Peptide Conjugates (CAPs) at Lipopolysaccharide Surface in Combating Gram-negative Bacterial Infections. J. Med. Chem. | DOI: 10.1021/acs.jmedchem.8b01357 (Just Accepted Manuscript)
    12. Yadav K, Yavvari PS, Pal S, Kumar S, Mishra D, Gupta S, Mitra S, Soni V, Khare N, Sharma P, Srikanth C.V, Kapil A, Singh A, Nandicoori V.K, Bajaj A. (2019) Oral Delivery of Cholic Acid-Derived Amphiphile Helps in Combating Salmonella-mediated Gut Infection and Inflammation Bioconjugate Chem. | DOI: 10.1021/acs.bioconjchem.8b00880 (Just Accepted Manuscript)
    13. Yavvari PS, Pal S, Kumar S, Kar A, Awasthi A,Naaz A, Srivastava A, Bajaj A (2017) An Injectable, Self-healing Chimeric Catechol-Fe(III) Hydrogel for Localized Combination Cancer Therapy ACS Biomaterials Sci. & Eng (In Press)
    14. Sreekanth V, Medatwal N, Kumar S, Pal S, Malyla V, Kar A, Bhargava P, Naaz A, Kumar N, Sengupta S, Bajaj A (2017) Tethering of Chemotherapeutic Drug/Imaging Agent to Bile Acid-Phospholipid Increases the Efficacy and Bioavailability with Reduced Hepatotoxicity. Bioconjugate Chem. (In Press).
    15. Kundu S, Bansal S, Muthukumarasamy KM, Sachidanandan C, Motiani r, Bajaj A (2017) Deciphering the Role of Hydrophobic and Hydrophilic Bile Acids in Angiogenesis using in vitro and in vivo Model Systems. MedChemComm (In Press).
    16. Kidwai S, Park C, Mawatwal S, Tiwari P, Jung MG., Gossain T, Kumar P, Alland D, Kumar S, Bajaj A, Hwang Y, Song CS, Dhiman R, Lee Y, Singh? R? (2017) The dual mechanism of action of 5-Nitro-1,10-Phenanthroline against Mycobacterium tuberculosis. Antimicrob Agents Chemother. ??[Epub ahead of print]
    17. Hussain T, Saha D, Purohit G, Kar A, Mukherjee AK , Sharma S, Sengupta S, Dhapola P, Maji B, Vedagopuram S, Horikoshi NT, Horikoshi N, Pandita RK, Bhattacharya S , Bajaj A, Riou JF, TK Pandita, Chowdhury S (2017) Transcription regulation of CDKN1A (p21/CIP1/WAF1) by TRF2 is epigenetically controlled through the REST repressor complex.Sci Rep. 7:11541
    18. Sreekanth? ?V?,? Medatwal? ?N?, Pal S?, Kumar S?, Sengupta S?, Bajaj A (2017) Molecular Self-Assembly of Bile Acid-Phospholipids Controls the Delivery of Doxorubicin and Mice Survivability? Mol. Pharm (Accepted)
    19. Yavvari P, Gupta S, Arora D,Nandicoori V, Srivastava A, Bajaj A (2017) Clathrin Independent Killing of Intracellular Mycobacteria and Biofilm Disruptions using Synthetic Antimicrobial Polymers, Biomacromolecules, Accepted
    20. Rana S, Elci SG, Mout R, Singla AK, Yazdani M, Bender M, Bajaj A, Saha K, Bunz UHF, Jirik FR, and Rotello VM, (2016) Ratiometric Array of Conjugated Polymers-Fluorescent Protein Provides a Robust Mammalian Cell Sensor. J. Am. Chem. Soc.138:4522
    21. Gupta S, Singh M, Reddy AM, Yavvari PS, Srivastava A, and Bajaj A. (2016) Interactions governing the entrapment of anticancer drugs by low molecular weight hydrogelator for drug delivery applications. RSC Adv. 6:19751
    22. Kundu S, Kumar S, Bajaj A. (2015)  Cross-talk between bile acids and gastrointestinal tract for progression and development of cancer and its therapeutic implications. IUBMB Life 67:514.
    23. S. Kumar, P. Bhargava, V. Sreekanth, and A. Bajaj, (2015) Design, Synthesis, and Physico-Chemical Interactions of Bile Acid Derived Dimeric Phospholipid Amphiphiles with Model Membranes. J. Colloid Interface Sci 448:398.
    24. K. Yadav, P. Bhargava, S. Bansal, M. Singh, S. Gupta, G. Sandhu, S. Kumar, V. Sreekanth, and A. Bajaj, (2015) Nature of the Charged Head Group Dictates the Anticancer Potential of Lithocholic Acid-Tamoxifen Conjugates For Breast Cancer Therapy, MedChemComm (Advance Article).
    25. A. Sharma, S. Bansal, A. A. Pohane, A. Bajaj, V. Jain, A. Srivastava. (2015) Cell-Penetrating Synthetic Antimicrobial Polypeptides (SAMPs) Exhibiting Potent and Selective Killing of Mycobacterium by Targeting its DNA. Chem Eur J 21:3540
    26. M Singh, S Bansal, S Kundu, P Bhargava, A Singh, R Motiani, R Shyam, V Sreekanth, S Sengupta, A Bajaj. (2015) Synthesis, Structure-Activity Relationship, and Mechanistic Investigation of Lithocholic Acid Amphiphiles for Colon Cancer Therapy. Med Chem Commun 6:192.
    27. Singh K, Verma V, Yadav K, Sreekanth V, Kumar D, Bajaj A, Kumar V. (2014) Design, Regioselective Synthesis and Cytotoxic Evaluation of 2-Aminoimidazole-quinoline Hybrids Against Cancer and Primary Endothelial Cells. Eur J Med Chem 87:150.
    28. Bansal S,  Singh M, Kidwai S, Bhargava P, Singh A, Sreekanth V, Kundu S, Singh R, Bajaj A. (2014) Bile Acid Amphiphiles with Tunable Head Groups as Highly Selective Non-hemolytic Antitubercular Agents. Med Chem Commun 5:1761.
    29. Singh M, Kundu S, Reddy A, Sreekanth V, Motiani R K, Sengupta S, Srivastava A, Bajaj A. (2014) Injectable small molecule hydrogel for localized and sustained in vivo delivery of Doxorubicin. Nanoscale 6:12849.
    30. Singh M, Bajaj A. (2014) Unraveling the Impact of Hydroxylation on Interactions of Bile Acid Cationic Lipids with Model Membranes by In-depth Calorimetry Studies. Phys Chem Chem Phys 16:19266.
    31. Bhargava P, Singh M, Sreekanth V, Bajaj A. (2014) Nature of the Charged Head Group Determines the Fusogenic Potential and Membrane Properties of Lithocholic Acid Phospholipids. J Phys Chem B 118:9341.
    32. Vedagopuram S, Bajaj A. (2013) Number of Free Hydroxyl Groups on Bile Acid Phospholipids Determines the Fluidity and Hydration of Model Membranes. J Phys Chem B 117:12135.
    33. Sharma S, Kundu S, Reddy AM, Bajaj A, Srivastava A. (2013) Design and Engineering of Stable and Biocompatible Disulfide-cross-linked Nanocomplexes of Polyamide Polyelectrolytes for Cytosolic Delivery of Entrapped Peptide Cargo. Macromol Biosci 13:927.
    34. Vedagapuram S, Bansal S, Motiani R, Kundu S, Muppu SK, Datta T, Panjamurthy K, Sengupta S, Bajaj A. (2013) Design, Synthesis and Mechanistic Investigations of Bile Acid-Tamoxifen Conjugates for Breast Cancer Therapy. Bioconjugate Chem 24:1468.
    35. Singh M, Singh A, Kundu S, Bansal S, Bajaj A. (2013) Interactions of Bile Acid based Facial Amphiphiles with Membranes Influences their Anticancer Activities for Colon Cancer. Biophys Biochim Acta Biomembr 1828:1926.
    36. Vedagopuram S, Bajaj A. (2013) Fluorescece (Fluidity/hydration) and Calorimetric Studies of Interactions of Bile Acid Tamoxifen Conjugates with Model Membranes. J Phys Chem B 117:2123.
    1. Rana S, Singla AK, Bajaj A, Elci SG, Miranda OR, Mout R, Yan B, Jirik FR, Rotello VM. (2012) Array-Based Sensing of Metastatic Cells and Tissues Using Nanoparticle-Fluorescent Protein Conjugates. ACS Nano 6:8233.
    2. Rana S, Bajaj A, Mout R, Rotello VM. (2011) Monolayer Coated Gold Nanoparticles for Delivery Applications. Adv Drug Del Rev 64:200.
    3. Saha K, Bajaj A, Duncan B, Rotello VM. (2011) Beauty is Skin Deep: A Surface Monolayer Perspective on Nanoparticle Interactions with Cells and Biomacromolecules. Small 7:1903. 
    4. Biswas J, Bajaj A, Bhattacharya S. (2011) Membranes of Cationic Gemini Lipids based on Cholesterol with Hydroxyl Headgroups and their Interactions with DNA and Phospholipid. J Phys Chem B 115:478.
    5. Subramani C, Saha K, Creran B, Bajaj A, Moyano DF, Wang H, Rotello VM. (2012) Cell Alignment Using Patterned Biocompatible Gold Nanoparticle Templates. Small 8:1209.
    6. Subramani C, Cengiz N, Saha K, Gevrek TN, Yu X, Jeong Y, Bajaj A, Sanyal A, Rotello VM. (2011) Direct Fabrication of Functional and Biofunctional Nanostructures Through Reactive Imprinting. Adv Mater 23:3165.
    7. Subramani C,Bajaj A, Miranda OR, Rotello VM. (2010) Biocompatible Charged and Uncharged Surfaces Using Nanoparticle Films. Adv Mater 22:5420.
    8. Bajaj A, Rana S, Miranda OR, Kim IB, Phillips RL,  Jerry DJ, Bunz UH, Rotello VM. (2010) Cell Surface-based Differentiation of Cell Types and Cancer States Using a Gold Nanoparticle-GFP Based Sensing Array. Chem Sci 1:134.
    9. Bajaj A, Miranda OR, Phillips R, Kim IB, Jerry DJ, Bunz UH, Rotello VM. (2010) Array Based Sensing of Mammalian Cell Types Using Conjugated Polymers. J Am Chem Soc 132:1018.
    10. Bajaj A, Miranda OR, Kim IB, Phillips RL, Jerry DJ, Bunz UH, Rotello VM. (2009) Detection and differentiation of normal, cancerous, and metastatic cells using nanoparticle-polymer sensor arrays. Proc Nat Acad Sci USA 106:10912.
    11. Bajaj A, Samanta B, Yan HH, Jerry DJ, Rotello VM. (2009) Stability, Toxicity and Differential Cellular Uptake of Protein Passivated-Fe3O4 Nanoparticles. J Mater Chem19:6328.
    12. Krebs MD, Erb RM, Yellen BB, Samanta B, Bajaj A, Rotello VM, Alsberg E. (2009) Formation of Ordered Cellular Structures in Suspension via Label-Free Negative Magnetophoresis. Nano Lett. 9:1812.
    1. Bhattacharya S, Bajaj, A. (2009) Recent Advances in Gene Delivery Through Molecular Design of Cationic Lipids. Chem Commun 6432.
    2. Bajaj A, Kondaiah P, Bhattacharya S. (2008) Gene Transfection Efficacies of Novel Cationic Gemini Lipids Possessing Aromatic Backbone and Oxyethylene Spacers. Biomacromolecules 9: 991.
    3. Bajaj A, Mishra S, Kondaiah P, Bhattacharya S. (2008) Effect of the headgroup variation on the gene transfer properties of cholesterol based cationic lipids possessing ether linkage. Biochim Biophys Acta: Biomembr 1778:1222.
    4. Bajaj A, Kondaiah P, Bhattacharya S. (2008) 'Effect of The Nature of Spacer on Gene Transfer Efficacies of Thiocholesterol Derived Gemini Lipids in Different Cell Lines: A Structure-Activity Investigation. J Med Chem 51:2533.
    5. Bajaj A, Paul B, Indi SS, Kondaiah P, Bhattacharya S. (2008) Structure-Activity Investigation on The Gene Transfection Efficiencies of Cariolipin Mimicking Gemini Lipid Analogues. Bioconjugate Chem 19:1283.
    6. Bhattacharya S, Bajaj, A. (2008) Fluorescence and Thermotropic Studies of The Interactions of PEI-Cholesterol Based Lipopolymers With Dipalmitoylphosphatidylcholine (DPPC) Membranes. Biochim Biophys. Acta: Biomembr 1778:2225.
    7. Bajaj A, Kondaiah P, Bhattacharya S. (2008) Synthesis and Gene Transfection Efficacies of PEI−Cholesterol-Based Lipopolymers. Bioconjugate Chem 19:1640.
    8. Bhattacharya S, Bajaj A. (2007) Membrane Forming Properties of Pseudoglyceryl Backbone Based Gemini Lipids Possessing Oxyethylene Spacers. J Phys Chem B 111:2463.
    9. Bajaj A., Kondaiah P, Bhattacharya S. (2007) Synthesis and Gene Transfection Properties of Novel Serum Compatible Cholesterol Based Gemini Lipids Possessing Oxyethylene Spacers. Bioconjugate Chem 18:1537.
    10. Bajaj A, Kondaiah P, Bhattacharya S. (2007) Design, Synthesis and In Vitro Gene Transfection Properties of Novel Cholesterol Based Gemini Lipids and Their Serum Compatibility: A structure-Activity Investigation. J Med Chem 50:2432.
    11. Bhattacharya S, Bajaj A. (2007) Thermotropic and Hydration studies of Gemini Pseudoglyceryl Lipids Possessing Polymethylene Spacers. Langmuir 23:8988.
    12. Bajaj A, Paul B, Indi SS, Kondaiah P, Bhattacharya S. (2007) Effect of the Hydrocarbon Chain Lengths and Spacer Lengths on Gene Transfection Efficacies of Gemini Lipids Based on Aromatic Backbone. Bioconjugate Chem 18:2144.
    13. Bhattacharya S, Bajaj A. (2007) Membrane-Forming Properties of Gemini Lipids Possessing Aromatic Backbone between the Hydrocarbon Chains and the Cationic Headgroup. J Phys Chem B 111:13511.
    14. Paul B, Bajaj A, Indi SS, Bhattacharya S. (2006) Synthesis of Novel Dimeric Lipids Based on an Aromatic Backbone Between the Hydrocarbon Chains and Head Groups. Tetrahedron Lett 47:8401.
    15. Bhattacharya S, Bajaj A. (2005) Recent Trends in Lipid Molecular Design. Curr Opin Chem Biol 9:647.

     

    • Dr. Vedagopuram Sreekanth
      Postdoctoral Research Fellow
      Brigham and Women's Hospital
      Harvard Medical School
      Broad Institute of MIT and Harvard
      415, Main St. Cambridge, MA 02142, USA.
      Contact: +1 (857) 999-6505
      Email: vsrikanth19@gmail.com
    • Dr.Somanath Kundu
      State University of New York
      Upstate Medical University
      Department of Neurosci & Physiology
      505 Irving Ave, Rm 3709
      Syracuse, NY 13210.
      Email: somnathkundu09@gmail.com
    • Dr. Kavita Yadav
      Email: yadav86kavita@gmail.com
    • Dr. Manish Singh
      Postdoctoral Research Fellow
      Nagoya Institute of Technology
      Showa-ku
      Nagoya 466-8555, Japan
      Email. maneeshsingh23@gmail.com
    • Dr. Sandhya Bansal
      Postdoctoral Research Fellow
      Norton Thoracic Institute
      St. Joseph's Hospital and Medical Center
      Dignity Health
      Phoenix-85013, Arizona, USA
      Contact: +16504459169
      Email: sandhyabansal@gmail.com
    • Dr. Rachana Trivedi
      Postdoctoral Research Fellow
      Geriatrics Department
      University of North Dakota
      Grand Forks, North Dakota-58201, USA.
      Contact:+17017398832
      Email: rachana.cdri@gmail.com
    • Dr. Rajender K Motiani
      Assistant Professor and Principal Investigator
      Laboratory of Calciomics and Systemic Pathophysiology (LCSP)
      Regional Centre for Biotechnology
      NCR Biotech Science Cluster
      Faridabad-121001, India
      Contact: +91-9717427369
      Email: rajender.motiani@rcb.res.in
    • Varsha Komalla
      PhD Candidate
      Graduate School of Health
      University of Technology Sydney
      67 Thomas Street, Ultimo
      NSW, Sydney, Australia-2007
      Email: varshakomalla56@gmail.com
    • Vamshikrishna Malyla
      PhD Student
      Centre for inflammation
      Centenary Institute
      Building 93, Royal Prince Alfred Hospital
      Missenden Rd (follow Johns Hopkins Drive)
      Camperdown, NSW 2050, Australia
      Contact: +61 434 978 439
      Email: vamshi.mk92@gmail.com , v.malyla@centenary.org.au
    • Mohammad Asad
      Project Assistant
      CSIR-Institute of Genomics and Integrative Biology, New Delhi
      Computational Structural Biology
      Contact: +917800915616
      Email: asadpharma786@gmail.com
    • Priyanshu Bhargava
      Researcher & Doctoral Candidate
      Biomedical Research Institute
      National Institute of Advanced Industrial Science & Technology (AIST)
      Central 4, 1-1-1 Higashi, Tsukuba, Ibaraki - 305 8562, Japan
      Email: bhargava.priyanshu@aist.go.jp
    • Sayan Dutta, Graduate Student
      Department of Medicinal Chemistry and Molecular Pharmacology
      Purdue Institute of Interdisciplinary Neuroscience
      Purdue University
      West Lafayette
      Indiana-47906, USA
      Email: sayanm06@gmail.com
      Phone: +1 2174187206
    • Omkar Kulkarni, PhD Student
      Department of Biological Sciences
      National University of Singapore (NUS), Singapore
      Email: komkar21@gmail.com
    • V. Madhukar,PhD Student
      Institute of Biomedicine
      Research Centre for Cancer, Infections and Immunity
      University of Turku
      Kiinamyllynkatu 10
      FI-20520 TURKU, Finland
      E-mail ID: madhukar.vedantham@utu.fi
      Phone no.: +358-402521503
    • P. BoomathiPandeswari
      CSIR-SRF
      Advanced centre for Bio-separation Technology (CBST)
      Vellore Institute of Technology (VIT)
      Vellore-632014,Tamil Nadu, India
      E-mail ID: boomathi.91@gmail.com
      Ph: +91-9566502605
    • Prithivi
      B.Tech
      Working on Halophilic Fungi
      PSG Groups
      Coimbatore
      Email: prithivitamil08@gmail.com
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