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Dr. Ramu S Vemanna

Assistant Professor
E-mail: ramu dot vemanna at rcb dot res dot in

  • PhD 2013, Bangalore University, Bangalore, India
  • Post Doc at Noble Research institute, Oklahoma, USA

Functional genomics and crop improvement for stress adaptation

My research focuses on understanding the basis of plant adaptation to drought to improve the productivity of our crops. Under natural environmental conditions, many stresses in combinations such as drought and pathogen or heat affect growth and productivity.

Under stress conditions, the acquired tolerant traits play a crucial role as a measure of cellular level tolerance (CLT). However, many complex process and mechanisms are involved in the regulation of CLT such as maintenance of redox homeostasis, regulation of gene expression, protein turnover, DNA/protein repair mechanisms, etc. The cumulative effect of all these processes results in survival, recovery, and productivity of plants under stress conditions. From this context, the emphasis of our research is on DNA repair and protein turnover mechanisms. The focus is to identify genes and genetic networks associated with protein turnover mechanisms and functional characterization of relevant genes using genome editing tools and chemical genomic approaches.

To maintain the genome integrity under stress DNA repair mechanisms are crucial which can control the epigenetic modifications, genome stability, and longevity, which can also be used to create genetic variability. Genome editing tools will be used to create genetic variability in rice, by targeting DNA mismatch repair genes. The whole genome Indels and drought tolerance in the variants will be assessed.

Emphasis is on Ribosomal proteins and E3 ligases involved in protein degradation mechanisms to improve protein turnover. The extra-ribosomal function of ribosomal proteins in abiotic stress will be studied. Plant E3 ligase targets will be identified and modulate their function using genome editing tools. The role of these genes in combined drought and bacterial blight causing Xanthomonas infection in rice will be studied to understand pathogenicity and improve plant health.
Another emphasis is to develop high throughput (HTP) chemical genomic platform to discover novel small molecules against bacterial pathogens and regulate plant processes under drought to improve crop yields.

  • Innovative Young Biotechnologist Award- (IYBA), 2016- 2020, DBT India
  • Ramanujan Fellow - DST, SERB -2017-22
  • CSIR-senior research Associate (Scientist pool) -December 2016 to April 2017
  • Fulbright-Nehru Postdoctoral Fellow- Sept 2014 to June 2016
  • Patent file No. 154/CHE/2012, “Selectable marker system”, Ramu S.V, Babitha K.C, Nataraja N Karaba, Udayakumar M,. Indian patent
  • Patent file No. 2646/CHE/2014, “An expression construct and its use for increasing abiotic stress tolerance in a plant cell”, Ramu S.V, Babitha K.C, Sheela. H.S, Prasad, T.G, Tuteja N, Udayakumar M,. Indian patent
  • Patent file No. 4195/CHE/2014, Herbicide tolerant multigene construct, Ramu S.V, Amaranatha, Reddy V, Udayakumar.M,. Indian Patent
  • G Keshavareddy, ARV Kumar, VS Ramu, Methods of Plant Transformation-A Review, Int. J. Curr. Microbiol.App. Sci, (2018) 7 (7), 2656-2668

  • G. KeshavareddyG. KeshavareddyA.R.V. KumarA. Makarla Udayakumar, Synthetic cry1AcF Gene Imparts Resistance to Spodoptera litura (F.) and Amsacta albistriga Walker in Peanut (Arachis hypogaea L.) cv. VRI-2 Aug 2018, Int. J. Curr. Microbiol. App. Sci. (2018) 7(8): 2567-2583

  • Raksha Singh, Seonghee Lee, Sunhee Oh, Vemanna S Ramu. Hee-Kyung Lee, Muthappa Senthil-Kumar, Wendy Daniela Fernandez-Bohorquez, Clemencia M Rojas, Kirankumar S Mysore, The Nonhost resistance protein 2B that functions in cell wall strengthening during plant immunity is a target for bacterial pathogens. (2018) MPMI-04-18-0094-R

  • Amita Kaundal*, Vemanna S Ramu*, Sunhee Oh, Seonghee Lee, Clemencia M. Rojas, Muthappa Senthil-Kumar, Kirankumar S Mysore. Degradation of GCN4 interacting RIN4 and 14-3-3 proteins reduce plasma membrane H+-ATPases activity and regulate stomatal opening and closing during pathogen attack. 2017. Plant cell, 29 (9), 2233-2248, DOI: * Equal contribution as first author

  • Preethi V, Vanitha P, Ramu S Vemanna, Sheshshayee MS, Udayakumar M Quantification of Membrane Damage/Cell Death Using Evan’s Blue Staining Technique. Bio-Protocol;. 7, 16, 2017

  • Nisarga KN*, Ramu S Vemanna*, Babitha KC, Mohan Raju BM, Udayakumar M. Aldo-ketoreductase 1 (AKR1) improves seed longevity in tobacco and rice by detoxifying reactive cytotoxic compounds generated during ageing. 2017. Rice Journal 10 (1), 11 * Equal contribution as first author

  • Ramu S Vemanna*, Babitha, KC, Jayant K Solanki, Amarnatha Reddy V, Sarangi S.K, Udayakumar M. Aldo-keto reductase-1 (AKR1) protect cellular enzymes from salt stress by detoxifying reactive cytotoxic compounds. Plant Physiology and Biochemistry, 2017. 113, 177-186

  • Vemanna S. Ramu, Amarnatha Reddy V, Murugesh Easwaran, Babitha K.C., Hanumantha Rao, Kirankumar Ghanti, Kirankumar S. Mysore, Udayakumar M. Aldo-keto reductase enzymes detoxify glyphosate and improve herbicide resistance in plants. 2017, Plant Biotechnology, 15 (7), 794-804

  • Vemanna S Ramu, Anjugam Paramanantham, Venkategowda Ramegowda, Basavaiah Mohan-Raju, Makarla Udayakumar and Muthappa Senthil-Kumar. Transcriptome analysis of sunflower genotypes with contrasting oxidative stress tolerance reveals individual- and combined- biotic and abiotic stress tolerance mechanisms. PlosOne 2016, 11 (6), e0157522

  • Satish Nagaraj, Muthappa Senthil-Kumar, Vemanna S. Ramu, Keri Wang, Kirankumar S. Mysore. Plant ribosomal proteins, RPL12 and RPL19, play a role in nonhost disease resistance against bacterial pathogens. 2016, Frontiers in Plant Science, 6: 1192. doi: 10.3389/fpls.2015.01192.

  • S.V Ramu, Swetha, T.N, H.S.Sheela, K.C. Babitha, P.Chandrashekar reddy, T.G. Prasad, M. Udayakumar. Simultaneous expression of regulatory genes associated with specific drought-adaptive traits improves drought adaptation in peanut. 2015, Plant Biotechnology Journal, doi: 10.1111/pbi.12461.

  • K.C. Babitha*, S.V. Ramu*, Karaba N. Nataraja, M. Udayakumar. Overexpression of EcbHLH57 transcription factor from Eleusine coracana L. in tobacco confers tolerance to salt, oxidative and drought stress, 2015, PLOS ONE, 10(9):e0137098. (*Equal contribution as first author)

  • K.C. Babitha*, S.V. Ramu*, Karaba N. Nataraja, Sheshshayee, M.S, M. Udayakumar. EcbZIP60, a basic leucine zipper transcription factor from Eleusine coracana L. improves abiotic stress tolerance in tobacco by activating unfolded protein response pathway, 2015, Molecular Breeding, 35:181. (*Equal contribution as first author)

  • Amaranatha Reddy Vennapusa, Ramu S. Vemanna, Rajashekar Reddy B. H., K. C. Babitha, K. Kiranmai, A. Nareshkumar, Chinta Sudhakar. An efficient callus induction and regeneration protocol for a drought tolerant rice Indica genotype AC39020. 2015, Journal of Plant Sciences, 3(5): 248-254

  • Hema Ramanna, Ramu S. Vemanna, Shivakumar Sreeramulu, Chandrasekhara P. Reddy, Muthappa Senthil-Kumar and Makarla Udayakumar. 2014. Stable expression of mtlD gene imparted multiple stress tolerance in finger millet. 2014, PLOS ONE, 9(6):e99110.

  • Ramu S. Vemanna, Babitha K. Chandrashekar, H. M. Hanumantha Rao, Shailesh K. Sathyanarayanagupta, K. S. Sarangi, Karaba N. Nataraja, M. Udayakumar. A modified multisite gateway cloning strategy for consolidation of genes in plants. 2013, Molecular Biotechnology, 53:129–138

  • Babitha K. Chandrashekar, Ramu S. Vemanna, Pruthvi V, Patil Mahesh, Karaba N. Nataraja, Makarla Udayakumar. Co-expression of AtbHLH17 and AtWRKY28 Confers Resistance to Several Abiotic Stresses in Arabidopsis. 2013, Transgenic research, 22(2):327-41

  • Mahesh Patil, S V Ramu, P Jathish, Rohini Sreevathsa, P Chandrashekar Reddy, T.G Prasad. Overexpression of AtNAC2 in Groundnut (Arachis hypogaea L.) improves abiotic stress tolerance. 2013, Plant Biotechnology Reports, 8(2): 161-169

  • Keshavareddy G, Rohini S, S. V. Ramu, Sundaresha S, A. R. V. Kumar, P. Ananda Kumar, Udayakumar Makarla. Transgenics in groundnut (Arachis hypogaea L.) expressing cry1AcF gene for resistance to Spodoptera litura (F.). 2013, Physiology and Molecular Biology of Plants. 19(3):343-52

  • S. V. Ramu, S. Rohini, G. Keshavareddy, M. Gowri Neelima, N. B. Shanmugam, A. R. V. Kumar,S. K. Sarangi, P. Ananda Kumar & M. Udayakumar. Expression of a synthetic cry1AcF gene in transgenic Pigeon pea confers resistance to Helicoverpa armigera. 2012, J of Applied Entomology. 136(9): 675–687

  • S.V. Ramu, K.C. Babitha, K.S. Shailesh, Karaba N Nataraja and M. Udayakumar. Modification of alkaline lysis method for rapid plasmid DNA isolation. 2011, Current biotica. Vol 4 Issue 3, ISSN 0973-4031

  • M.Gowri neelima, S.V. Ramu, Rohini Sreevthsa, B.M. Asha Rani, A.R.V. Kumar, M.C. Gayathri. Inplanta transformation strategy to generate transgenic plants in chick pea: proof of concept with a cry gene. 2008, Indian Journal of Plant Biology, Vol 35, No 3, 201-206

  • 23. Mahesh salimat and Ramu.S.V. Fate of nutrients in Food. 2009, AGROBIOS Newsletter. Vol VIII, Issue No.3, p62-63 agrbiosindia.

  • Book chapters

  • Udayakumar M, Ramu S Vemanna, D Prathibha, Gowsiya Shaik, S Mahesh, GJ Pavithra, MS Sheshshayee. Adaptation of Crops to Climate Change: Relevant Mechanisms and their Genetic Enhancement. Agriculture under Climate Change: Threats, Strategies and Policies. Allied Publishers. 2017, 1: 126

  • Ramu S Vemanna, Babitha K C, Kirankumar S Mysore. RNAi and microRNA technologies to combat plant insect pests. Chandrakanth Emani (Ed). The biology of plant-insect interactions: a compendium for plant biotechnologists. Science Publishers/CRC Press, Taylor & Francis Group: ISBN 9781498709736. 150-177

  • Ramu SV, Rohini Sreevathsa, Sarangi S.K, Udayakumar M. Plant protection through RNAi: Alternative for pesticides and chemical approaches to pest control. In book Genetically Engineered Crops: Biotechnology, Biosafety and Benefits. Lindsay M. Grover(Ed) Nova publications. 2010, (ISBN: 978-1-61122-526-6)

Dr. Ramu S Vemanna
Regional Centre for Biotechnology
NCR Biotech Science Cluster
3rd Milestone, Faridabad-Gurgaon Expressway
P.O. Box No. 3, Faridabad - 121 001
Haryana (NCR Delhi), India
E-mail: ramu dot vemanna at rcb dot res dot in
Phone: 91 129-2848713 

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