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Dr. Chittur V Srikanth

Professor
E-mail: cvsrikanth at rcb dot res dot in

  • PhD 2005, Institute of Microbial Technology
  • Postdoc at Harvard Medical School, USA & University of Massachusetts Medical School, USA
  • Professor

Research in my lab is broadly directed at understanding the key events that cause inflammation during infections and autoimmune disorders of gastrointestinal tract. Specifically, we work on very important human diseases which arise due to bacterial infections and immune disorders. Our key interests are: (i) Host-Salmonella crosstalk, (ii) Persistent Salmonella infections, (iii) Gut microbiota and its connection to human diseases, (iv) Intestinal autoimmune disorders, (v) Molecular mechanisms of colorectal cancer and gallbladder cancer.

We focus on model bacterial pathogen Salmonella Typhimurium with an ultimate goal to understand molecular mechanisms underlying its pathogenesis. The gram negative, facultative intracellular bacterial pathogen Salmonella is one of the most frequent causes of acute gastroenteritis in humans. The disease results from a complex cascade of interactions between the pathogenic bacterium, the host intestinal epithelium, the commensal microbiota and the immune system of the host. Each of these entities are of interest to us. The disease manifestation is characterized histologically by massive infiltration of neutrophils (PMN), a phenotype also observed in some of the chronic autoimmune diseases of the gut such as Crohn’s disease (CD) and ulcerative colitis (UC). In the recent times, there has been a sudden increase in incidence of CD and UC.

Crohn’s disease (CD) and ulcerative colitis (UC) are serious autoimmune disorders which are now on a rise. Uncontrolled inflammation contributes to the pathogenesis of inflammatory diseases as well as the development of cancers. We are also working on inflammation induced gastrointestinal cancers.

Using state of the art tools of microbiology, molecular biology and fluorescent-imaging and proteomics, our group probes complex mechanisms operational during these illnesses. We utilise cell culture model , murine model(s), organotypic models and human patient samples to carry out these investigations. We have long standing collaborations with clinicians and experts in the field which has allowed us to create our own niche in the field. We have been examining the involvement of post-tranlational modification (PTMs) pathways in shaping inflammatory processes of gut. Our recent paradigm shifting discovery, demonstrating the critical role of SUMOylaiton in modulation of gut homeostasis has opened up several exciting avenues in biology of infectious diseases and GI illnesses. In future, we aim to dissect the precise role of PTM pathways in governing epithelial-immune crosstalk particularly in the context of intestinal inflammation. The ultimate goal is not only to combat bacterial pathogenesis but also find therapeutic solutions to auto-immune disorders.

  • Wellcome-DBT Intermediate Fellow
  • S Nandha Kumar
    Masters dissertation scholar
    snandha.kumar@rcb.res.in
  • Pharvendra Kumar
    Junior Research fellow
    pharvendra.k@rcb.res.in
  • Yesheswini rajendran
    INT-PhD student
    yesheswini.rajendran@rcb.res.in
  • Rohan Babar
    Senior Research Fellow
    rohan.babar@rcb.res.in
  • Sonalika Maurya
    Junior Research Fellow
    sonalika@rcb.res.in
  • Preksha Gaur
    Junior Research Fellow
    preksha@rcb.res.in
  • Hridya Chandrasekar
    Junior Research Fellow
    hridya@rcb.res.in
  • Mr. Pappu Bharti Lab Attendant
  • Lab Alumni

  • Dr. Smriti Verma : Young Investigator
  • Dr. Gayatree Mohapatra : Junior Research fellow
  • Dr. Salman Ahmad Mustfa : Junior Research fellow
  • Dr. Sarika Rana : Junior Research fellow
  • Dr. Syed Mohd. Aamir Suhail : Junior Research fellow
  • Dr. Mukesh Kumar : Post Doctoral
  • Dr. Prabhakar : Young Investigator
  • Ms Swati Jain : Project Fellow
  • Ms Navneet Kaur : Junior Research Fellow
  • Dr. Preety Bajwa : Project Fellow
  • Ms. Neha Yadav : Junior Research Fellow
  • Ms. Garima Chamoli : Junior Research Fellow
  1. Rana S, Maurya S, Mohapatra G, Singh S, Babar R, Chandrasekhar H, Chamoli G, Rathore D, Kshetrapal P, Srikanth CV. (2021) Activation of epigenetic regulator KDM6B by Salmonella Typhimurium enables chronic infections. Gut Microbes. 2021 Jan-Dec;13(1):1986665.
  2. Rana S, Maurya S, Chadrasekhar H, Srikanth CV. (2021) Molecular determinants of peaceful coexistence versus invasiveness of non-Typhoidal Salmonella: Implications in long-term side-effects. Mol Aspects Med. 2021 Oct;81:100997
  3. Verma P, Srivastava A, Srikanth CV, Bajaj A. (2021) Nanoparticle-mediated gene therapy strategies for mitigating inflammatory bowel disease. Biomater Sci. 2021 Mar 10;9(5):1481-1502.
  4. Preksha G, Yesheswini R, Srikanth CV. (2021) Cell culture techniques in gastrointestinal research: Methods, possibilities and challenges. Indian J Pathol Microbiol. 2021
  5. Awasthi A, Nain V, Srikanth CV, Puria R. (2020) A regulatory circuit between lncRNA and TOR directs amino acid uptake in yeast. Biochim Biophys Acta Mol Cell Res. 2020 Jun;1867(6):118680.
  6. Suhail A, Rizvi ZA, Mujagond P, Ali SA, Gaur P, Singh M, Ahuja V, Awasthi A, Srikanth CV. (2019) DeSUMOylase SENP7-Mediated Epithelial Signaling Triggers Intestinal Inflammation via Expansion of Gamma-Delta T Cells. Cell Rep | 3522-3538
  7. Yavvari PS, Verma P, Mustfa SA, Pal S, Kumar S, Awasthi AK, Ahuja V, Srikanth CV *, Srivastava A*, Bajaj A*. A nanogel based oral gene delivery system targeting SUMOylation machinery to combat gut inflammation. Nanoscale. 2019 Mar 14;11(11):4970-4986. (* co-corresponding authors)
  8. Yadav K, Yavvari PS, Pal S, Kumar S, Mishra D, Gupta S, Mitra M, Soni V, Khare N, Sharma P, Srikanth CV, Kapil A, Singh A, Nandicoori VK, Bajaj A. Oral Delivery of Cholic Acid-Derived Amphiphile Helps in Combating Salmonella-Mediated Gut Infection and Inflammation. Bioconjug Chem. 2019 Mar 20;30(3):721-732.
  9. Mohapatra G, Gaur P, Mujagond P, Singh M, Rana S, Pratap S, Kaur N, Verma S, Krishnan V, Singh N, Srikanth CV. A SUMOylation-dependent switch of RAB7 governs intracellular life and pathogenesis of Salmonella Typhimurium. J Cell Sci. 2019 Jan 11;132(1).
  10. Awasthi A, Kumar P, Srikanth CV, Sahi S, Puria R. Invitro Evaluation of Torin2 and 2, 6-Dihydroxyacetophenone in Colorectal Cancer Therapy. Pathol Oncol Res. 2019 Jan;25(1):301-309.
  11. Mustfa SA, Singh M, Suhail A, Mohapatra G, Verma S, Chakravorty D, Rana S, Rampal R, Dhar A, Saha S, Ahuja V, Srikanth CV (2017) SUMOylation pathway alteration coupled with downregulation of SUMO E2 enzyme at mucosal epithelium modulates inflammation in inflammatory bowel disease. Open Biol 7: 170024
  12. Srikanth CV, Verma S (2017) Sumoylation as an Integral Mechanism in Bacterial Infection and Disease Progression. Adv Exp Med Bio 963:389
  13. Verma S, Srikanth CV. (2015)  Understanding the complexities of Salmonella-host crosstalk as revealed by in vivo model organisms. IUBMB Life 67:482.
  14. Verma S, Mohapatra G, Ahmed SM, Rana S, Jain S, Khalsa JK, Srikanth CV. (2015)  Salmonella engages host microRNAs to modulate SUMOylation: a new arsenal for intracellular survival. Mol Cell Biol.Jun 22. pii: MCB.00397-15. [Epub ahead of print] PubMed PMID: 26100020.
  15. Hallstrom KN, Srikanth CV, Agbor TA, Dumont CM, Peters KN, Paraoan L, Casanova JE, Boll EJ, McCormick BA (2015) PERP, a host tetraspanning membrane protein, is required for Salmonella-induced inflammation. Cell Microbiol. Jun;17(6):843-59. doi: 10.1111/cmi.12406. Epub 2015 Jan 24. PubMed PMID: 25486861.
  16. Srikanth CV, Mercado-Lubo R, Hallstrom K, McCormick BA. (2011) Salmonella effector proteins and host-cell responses. Cell Mol Life Sci 68(22):3687.
  17. Wall DM, Srikanth CV, McCormick BA. (2010) Targeting tumors with salmonella Typhimurium- potential for therapy. Oncotarget 1(8):721.
  18. Srikanth CV, Wall, DM, Ana Maldonado-Contreras, Haining Shi, Daoguo Zhou, Zachary Demma, Mumy, KL, McCormick BA. (2010) Salmonella pathogenesis and processing of secreted effectors by caspase- 3. Science 330:390.
  19. Johnson EE, Srikanth CV, Sandgren A, Harrington L, Trebica E, Wang L, Borregaard N, Murray M, Cherayil BJ. (2010) Siderocalin inhibits the intracellular replication of Mycobacterium tuberculosis in macrophges. FEMS Immunolo Med Microbiol 58(1):138.
  20. Kumar CM, Khare G, Srikanth CV, Tyagi AK, Sardesai AA, Mande SC. (2009) Facilated oligomerization of Mycobacterial GroEL: Evidence for Phosphorylation-mediated oligomerization J Bacteriol 191(21):6525.
  21. Kaur J, Srikanth CV, Bachhawat AK. (2009) Differential roles played by the native cysteine residues of the yeast glutathione.transporter, Hgt1p. Manuscript accepted for publication in FEMS Yeast Res 9(6):849.
  22. Srikanth CV,  McCormick BA. (2008) Interactions of the Intestinal Epithelium with the Pathogen and the Indigenous Microflora: A Three Way Crosstalk Interdiciplinary perspective of Infectious diseases. 626827:1.
  23. Harrington L, Srikanth CV, Antony R, Rhee SJ, Mellor AL, Shi HN, Cherayil BJ. (2008) Deficiency of indoleamine 2,3-dioxygenase enhances commensal-induced antibody responses and protects against Citrobacter rodentium-induced colitis. Infect Immun 76(7):3045.
  24. Harrington L, Srikanth CV, Antony R, Shi HN, Cherayil BJ. (2007) A role for natural killer cells in intestinal inflammation caused by infection with Salmonella enterica serovar Typhimurium. FEMS Immunol Med Microbiol 51(2):372.
  25. Srikanth CV, Cherayil BJ. (2007) Intestinal innate immunity and the pathogenesis of Salmonella enteritis. Immunol Res 37(1):61.
  26. Srikanth CV, Vats P, Bourbouloux A, Delrot S, Bachhawat AK. (2005) Multiple cis-regulatory elements and the yeast sulphur regulatory network are required for the regulation of the yeast glutathione transporter, Hgt1p. Curr Genet 47(6):345.
  27. Srikanth CV, Chakraborti AK, Bachhawat AK. (2005) Acetaminophen toxicity and resistance in the yeast Saccharomyces cerevisiae. Microbiology 151(Pt 1):99-111.
  28. Kohli DK, Srikanth CV, Bachhawat AK. (2004) A search tool for identification and analysis of conserved sequence patterns in Saccharomyces spp. orthologous promoter. In Silico Biol 4(4):411.
  29. Zhang MY, Bourbouloux A, Cagnac O, Srikanth CV, Rentsch D, Bachhawat AK, Delrot S. (2004) A novel family of transporters mediating the transport of glutathione derivatives in plants. Plant Physiol 134(1):482.
  30. Ganguly D, Srikanth CV, Kumar C, Vats P, Bachhawat AK. (2003) Why is glutathione (a tripeptide) synthesized by specific enzymes while TSH releasing hormone (TRH or thyroliberin), also a tripeptide, is produced as part of a pherohormone protein?. IUBMB Life 55(9):553.

Dr. Chittur V Srikanth
Professor
Regional Centre for Biotechnology
NCR Biotech Science Cluster
3rd Milestone, Faridabad-Gurgaon Expressway
P.O. Box No. 3, Faridabad - 121 001
Haryana (NCR Delhi), India
E-mail: cvsrikanth at rcb dot res dot in
Phone: 91 129-2848820

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