E-mail: Vrati at rcb dot res dot in, director at rcb dot res dot in
RNA virus replication and vaccine development
Japanese Encephalitis virus (JEV) is a member of the Flaviviridae family of animal viruses that contains several other medically important viruses such as Dengue and Yellow fever. JEV is a major cause of human encephalitis and is responsible for considerable mortality and morbidity in India. Frequent epidemics of Japanese encephalitis (JE) are being reported from various parts of India and JEV has become endemic in several parts of the country. We are studying the replication of JEV and investigating the role of the cellular proteins in virus replication. We are also examining the potential of small nucleic acid molecules such as siRNA and DNAzymes for inhibiting JEV replication.
Our group also focuses on key aspects of the JEV life-cycle like receptor-binding and entry mechanisms, molecular mechanisms of virus replication, assembly and egress. The virus infectious-cycle involves a complex interaction between virus and host proteins. We are employing JEV- recombinant proteins and infectious viruses as exploratory systems in combination with molecular biology, cell biology and proteomic approaches. These studies provide insight into JEV pathogenesis, and have the potential to offer therapeutic interventions.
Our laboratory is also involved in the clinical development an oral rotavirus vaccine for children. Besides, we are interested in developing novel adenoviral vectors useful for vaccine delivery.
Prof. Sudhanshu Vrati
Regional Centre for Biotechnology
NCR Biotech Science Cluster
3rd Milestone, Faridabad-Gurgaon Expressway
P.O. Box No. 3, Faridabad - 121 001
Haryana (NCR Delhi), India
E-mail: Vrati at rcb dot res dot in
Phone: 91 129 2848801